-
25. EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling
Hu Z#, Chen PH#, Li W#, Krone M, Zheng S, Saarbach J, Velasco IU, Hines J, and Crews CM. (# equal contribution)
Science Advances 2024 March 27
-
24. Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality
Hu Z*, Chen PH*, Li W, Douglas T, Hines J, Liu Y, and Crews CM. (* equal contribution)
J. Am. Chem. Soc. 2023 Feb 8
https://pubs.acs.org/doi/10.1021/jacs.2c11706
More about proximity-induced molecules:
-
------------after joining NCKU------
-
23. Identification and targeting of a HES1‐YAP1‐CDKN1C functional interaction in fusion‐negative rhabdomyosarcoma
Kovach AR, Oristian KM, Kirsch DG, Bentley RC, Cheng C, Chen X, Chen PH, Chi JT, and Linardic CM.
Molecular Oncology. 2022 Aug 11
doi: 10.1002/1878-0261.13304.
-
22. Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs).
Chen PH*, Hu Z*, An E, Okeke I, Zheng S, Luo X, Gong A, Jaime-Figueroa S, and Crews CM. (*equal contribution)
ACS Chem Biol. 2021 Dec 17;16(12):2808-2815.
Highlighted in Trends in Pharmacological Sciences (https://doi.org/10.1016/j.tips.2022.01.005)
-
21. Unexpected zinc dependency of ferroptosis: what is in a name?
Chen PH, Chi JT.
Oncotarget. 2021 Jun 8;12(12):1126-1127. doi: 10.18632/oncotarget.27951. eCollection 2021 Jun 8.
-
20. The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2.
Yang WH, Lin CC, Wu J, Chao PY, Chen K, Chen PH, Chi JT.
Mol Cancer Res. 2021 Jun;19(6):1005-1014. doi: 10.1158/1541-7786.MCR-20-0534.
-
19. DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway.
Lin CC, Yang WH, Lin YT, Tang X, Chen PH, Ding CC, Qu DC, Alvarez JV, Chi JT.
Oncogene. 2021 Mar;40(11):2018-2034.
-
18. Zinc transporter ZIP7 is a novel determinant of ferroptosis.
Chen PH*, Wu J*, Xu Y, Ding CC, Mestre AA, Lin CC, Yang WH, and Chi JT. (*equal contribution)
Cell Death Dis. 2021 Feb 19;12(2):198. doi: 10.1038/s41419-021-03482-5.
-
17. A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and Notch signaling.
Slemmons KK, Deel MD, Lin YT, Oristian KM, Kuprasertkul N, Genadry KC, Chen PH, Chi JT, Linardic CM.
Biol Open. 2021 Feb 9;10(2).
-
16. The Intersection of DNA Damage Response and Ferroptosis-A Rationale for Combination Therapeutics.
Chen PH, Tseng WH, Chi JT.
Biology (Basel). 2020 Jul 23;9(8). doi: 10.3390/biology9080187. Review.
-
15. MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis.
Ding CC, Rose J, Sun T, Wu J, Chen PH, Lin CC, Yang WH, Chen KY, Lee H, Xu E, Tian S, Akinwuntan J, Zhao J, Guan Z, Zhou P, Chi JT.
Nat Metab. 2020 Mar;2(3):270-277.
-
14. Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism.
Chen PH, Wu J, Ding CC, Lin CC, Pan S, Bossa N, Xu Y, Yang WH, Mathey-Prevot B, Chi JT.
Cell Death Differ. 2020 Mar;27(3):1008-1022.
-
13. Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment.
Chen PH, Hu J, Wu J, Huynh DT, Smith TJ, Pan S, Bisnett BJ, Smith AB, Lu A, Condon BM, Chi JT*, Boyce M*.
JCI Insight. 2020 Jan 16;5(1).
-
12. Functional crosstalk among oxidative stress and O-GlcNAc signaling pathways.
Chen PH, Chi JT*, Boyce M*.
Glycobiology. 2018 Aug 1;28(8):556-564. doi: 10.1093/glycob/cwy027. Review.
-
11. KEAP1 has a sweet spot: A new connection between intracellular glycosylation and redox stress signaling in cancer cells.
Chen PH, Chi JT*, Boyce M*.
Mol Cell Oncol. 2017;4(6):e1361501.
-
10. Glycosylation of KEAP1 links nutrient sensing to redox stress signaling.
Chen PH, Smith TJ, Wu J, Siesser PF, Bisnett BJ, Khan F, Hogue M, Soderblom E, Tang F, Marks JR, Major MB, Swarts BM, Boyce M*, Chi JT*.
EMBO J. 2017 Aug 1;36(15):2233-2250.
-
9. Discovery, Genomic Analysis, and Functional Role of the Erythrocyte RNAs.
Chen PH, Hong J, Chi JT.
Current Pathobiology Reports (2017)
-
8. An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage.
Inoue M, Chen PH, Siecinski S, Li QJ, Liu C, Steinman L, Gregory SG, Benner E, Shinohara ML.
Nat Neurosci. 2016 Dec;19(12):1599-1609.
-
7. Conditional Knockout of Breast Carcinoma Amplified Sequence 2 (BCAS2) in Mouse Forebrain Causes Dendritic Malformation via β-catenin.
Huang CW, Chen YW, Lin YR, Chen PH, Chou MH, Lee LJ, Wang PY, Wu JT, Tsao YP, Chen SL.
Sci Rep. 2016 Oct 7;6:34927.
-
6. Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma.
Kephart JJ, Tiller RG, Crose LE, Slemmons KK, Chen PH, Hinson AR, Bentley RC, Chi JT, Linardic CM.
Clin Cancer Res. 2015 Nov 1;21(21):4868-80.
-
5. BCAS2 Regulates Delta-Notch Signaling Activity through Delta Pre-mRNA Splicing in Drosophila Wing Development.
Chou MH, Hsieh YC, Huang CW, Chen PH, Chan SP, Tsao YP, Lee HH, Wu JT, Chen SL.
PLoS One. 2015;10(6):e0130706.
-
4. Syngeneic murine ovarian cancer model reveals that ascites enriches for ovarian cancer stem-like cells expressing membrane GRP78
Mo L, Bachelder RE, Kennedy M, Chen PH, Chi JT, Berchuck A, Cianciolo G, Pizzo SV.
Molecular Cancer Therapeutics. 2015 March
-
3. BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing.
Chen PH, Lee CI, Weng YT, Tarn WY, Tsao YP, Kuo PC, Hsu PH, Huang CW, Huang CS, Lee HH, Wu JT, Chen SL.
RNA. 2013 Feb;19(2):208-18.
-
2. RssAB signaling coordinates early development of surface multicellularity in Serratia marcescens.
Tsai YH, Wei JR, Lin CS, Chen PH, Huang S, Lin YC, Wei CF, Lu CC, Lai HC.
PLoS One. 2011;6(8):e24154.
-
1. Breast cancer amplified sequence 2, a novel negative regulator of the p53 tumor suppressor.
Kuo PC, Tsao YP, Chang HW, Chen PH, Huang CW, Lin ST, Weng YT, Tsai TC, Shieh SY, Chen SL.
Cancer Res. 2009 Dec 1;69(23):8877-85.